Propranolol (inderal) in Disturbances of Cardiac Rhythm.

Acute and chronic effects of an adrenergic beta-receptor blocking agent (propranolol) in treatment of cardiac arrhythmias.

THE INTRODUCTION of the adrenergic beta-receptor blocking agent, pronethalol,1 and the more recent availability of its analogue propranolol2 have served as a new impetus in the pharmacological study of the cardiovascular system. Clinical use of these compounds has been explored in the treatment of hypertension,3 angina pectoris,4 prolonged systemic hypotension,5 hypertrophic subaortic stenosis,...

Double-blind Trial of Propranolol (inderal) in Angina Pectoris.

Effect of Propranolol (inderal) in Angina Pectoris: Preliminary Report.

Double-blind Trial of Propranolol (inderal) in Angina of Effort.

Blockade of adrenergic beta-receptors has a possible application in the management of angina of effort, presumably through reduction of exercise-induced tachycardia and thereby of total cardiac work. A clinical trial with pronethalol has shown encouraging results (Alleyne et al., 1963). Its further use has, however, been limited partly by frequent central-nervous-system side-effects and partly ...

Beta-adrenergic blockade in angina pectoris: a method of treadmill assessment.

sympathetic innervation of the heart, and the cardiac cts of circulating catecholamines, are mediated through drenergic receptors. The increase in heart rate, and the -eased power of contraction normally produced by sympa:ic stimulation, can be prevented by the recently introduced !ceptor blocking agents, which therefore modify the haemoamic response to exercise. Pronethalol (Alderlin) was the ...